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Pharmaceutical Engineering:   Offered by the Department of Chemical Engineering.
 
GRADUATE COURSES:

PhEn 500 - Pharmaceutical Engineering Fundamentals I (3 credits)
Prerequisite: undergraduate calculus. This is a required bridge course for those students who are admitted to the Pharmaceutical Engineering MS program without an undergraduate engineering degree. This course is not counted toward degree credit related to the Pharmaceutical Engineering MS program. The course covers the fundamentals of calculus, differential equations, probability and statistics, and finance business mathematics applied to pharmaceutical engineering problems and illustrated through pharmaceutical engineering examples.

PhEn 501 - Pharmaceutical Engineering Fundamentals II (3 credits)
Prerequisite: If needed, PhEn 500 (which can also be taken concurrently with this course), as well as an undergraduate course in physical chemistry. This course is a required bridge course for those students who are admitted to the Pharmaceutical Engineering MS program without an undergraduate engineering degree or with an engineering background that did not include the topics covered in this course. The course is not counted toward degree credit related to the Pharmaceutical Engineering MS program. The course covers the fundamentals of pharmaceutical engineering calculations related to material and energy balances applied to pharmaceutical facilities and systems; estimation of thermophysical properties, phase and reaction equilibrium; and chemical kinetics and basic reactor design.

PhEn 502 - Pharmaceutical Engineering Fundamentals III (3 credits)
Prerequisite:If needed, PhEn 500 and PhEn 501, as well as undergraduate course in physical chemistry. This is a required bridge course for those students who are admitted to the Pharmaceutical Engineering MS program without an undergraduate engineering degree or with an engineering background that did not include the topics covered in this course. The course is not counted toward degree credit related to the Pharmaceutical Engineering MS program. The course covers the fundamentals of fluid mechanics, heat transfer, mass transfer and the design of unit operations involving these principles.

PhEn 590 - Graduate Co-op Work Experience I (3 additive credits)
Prerequisite: permission from Pharmaceutical Engineering Program Advisor and Division of Career Development Services. Cooperative education internship provides on-the-job reinforcement of the academic program by placement in major-related work situations at pharmaceutical companies or companies serving the pharmaceutical industry. Work assignment developed or approved by the co-op office and evaluated by the department. Cannot be used for degree credit.

PhEn 591 - Graduate Co-op Work Experience II (3 additive credits)
Prerequisite: permission from Pharmaceutical Engineering Program Advisor and Division of Career Development Services. Same range of activities as in PhEn 590.

PhEn 592 - Graduate Co-op Work Experience III (3 additive credits)
Prerequisite: permission from Pharmaceutical Engineering Program Advisor and Division of Career Development Services. Same range of activities as in PhEn 590 and PhEn 591.

PhEn 593 - Graduate Co-op Work Experience IV (0 credits)
Prerequisites: One immediately prior 3-credit registration for graduate co-op work experience with the same employer. Requires approval of departmental co-op advisor and the Division of Career Development Services. Must have accompanying registration in a minimum of 3 credits of course work. Effective From: Fall 2006

PhEn 601 - Principles of Pharmaceutical Engineering (3 credits )
This course provides an overview of the pharmaceutical industry, including basic information about drug discovery and development, FDA requirements and approval processes, drug dosage forms, and the role of key operational units in drug manufacturing processes. This course enables the students to: understand the role of the pharmaceutical industry in the global market and its implications; learn the fundamentals of the drug development cycle and the investment required to bring a drug to market; learn the most important drug manufacturing processes and the key elements of dosage formulation.

PhEn 602 - Pharmaceutical Facility Design (3 credits)
Prerequisite: PhEn 601, PhEn 603; undergraduate courses in differential equations and fluid flow or completion of bridge program for students who are required to take it. This course provides instruction in design of state-of-the art pharmaceutical facilities for both manufacturing and R&D, by identifying key functional requirements and design concepts necessary to pharmaceutical processes. Interdisciplinary training will be provided in appropriate areas of facility design.

PhEn 603 - Pharmaceutical Unit Operations: Processing of Liquid and Dispersed Phase Systems (3 credits )
This course examines methodologies, both applied and fundamental, to analyze and scale up manufacturing pharmaceutical processes involving liquid and dispersed-phase systems, such as liquid and multiphase mixing, sterilization and sanitation, lyophilization, filtration, centrifugation and others. The emphasis is primarily on the engineering aspects of the parmaceutical processes examined in the course. Effective From: Fall 2006

PhEn 604 - Validation and Regulatory Issues in the Pharmaceutical Industry (3 credits )
This course is focused on the development of a working knowledge of the Federal Code of Regulations and its impact on the pharmaceutical and allied industries. The history of the Federal Government's regulation of the pharmaceutical industry is studied. Also covered is the industry's response and the methodologies it uses to comply with these regulations.

PhEn 605 - Pharmaceutical Packaging Technology (3 credits)
Prerequisite: PhEn 601, PhEn 603, and completion of the bridge program for students who are required to take it. This course focuses on developing a working knowledge of the machinery and unit operations used in transferring a drug substance in the bulk final form to a finished product ready for sale to the consuming public. Packaging of both liquid and solid forms in various types of delivery containers such as vials/ampoules, blister packs, individual packets, bottles, pouches and syringes is examined. The cleaning, sterilization and scaling/capping required for each dosage form is discussed, as well as freeze-drying, tableting capsule filling, and form/fill/seal, and proper labeling of final drug forms.

PhEn 606 - Pharmaceutical Unit Operations: Solids Processing (3 credits)
This course examines methodologies, both applied and fundamental, to analyze and scale up manufacturing pharmaceutical processes involving solids processing, such as solids characterization, blending, milling, granulation, tableting, coating, and others. The emphasis is primarily on the engineering aspects of the pharmaceutical processes examined in the course.

PhEn 612 - Pharmaceutical Reaction Engineering (3 credits)
Prerequisite: PhEn 601, PhEn 603; undergraduate courses in differential equations and chemical engineering kinetics, or completion of bridge program for students who are required to take it. This course examines a variety of reactions and reactors typically encountered in the pharmaceutical industry, including single/multiphase systems (e.g., crystallization), chemical synthesis, enzymatic, bio-reactions (fermentation), and others. The course then focuses on quantitative pharmaceutical reactor design and scale-up issues.

PhEn 614 - Pharmaceutical Separation Processes (3 credits)
This course covers separation processes in general and pharmaceutical separations in particular. Specific processes to be studied include distillation, extraction, crystallization, adsorption, ion exchange, chromatography, moving bed processes, electrophoresis, freeze drying, microfiltration/ultrafiltration, reverse osmosis, and pervaporation.

PhEn 618 - Principles of Pharmacokinetics and Drug Delivery (3 credits)
The course covers the basic principles of pharmacokinetics, including drug transport, parenteral and enteral routes of drug administration, and factors affecting drug absorption, distribution, metabolism, and excretion. Mathematical pharmacokinetic models and drug delivery processes are also presented and quantitatively studied.

PhEn 698 - Special Topics in Pharmaceutical Engineering I (3 credits)
Prerequisite: graduate standing and permission of the instructor. Topics of current interest in pharmaceutical engineering.

PhEn 699 - Special Topics in Pharmaceutical Engineering II (3 credits)
Prerequisite: graduate standing and permission of the instructor. Topics of current interest in pharmaceutical engineering.

PhEn 700 - Master's Thesis (3 credits)
Prerequisite: matriculation for the Master's degree in pharmaceutical engineering. Approval of thesis advisor is necessary for registration. Original research under the guidance of a departmental advisor. The final product must be a written thesis approved by at least three faculty members: the primary advisor, another from the pharmaceutical engineering faculty, and one other faculty member. A student must continue to register for at least 3 credits per semester until at least 6 credits have been completed and a written thesis is approved. Only a total of 6 credits will count toward the degree.

PhEn 701 - Master's Thesis (6 credits)
Prerequisite: matriculation for the Master's degree in pharmaceutical engineering. Approval of thesis advisor is necessary for registration. Original research under the guidance of a departmental advisor. The final product must be a written thesis approved by at least three faculty members: the primary advisor, another from the pharmaceutical engineering faculty, and one other faculty member. A student must continue to register for at least 3 credits per semester until at least 6 credits have been completed and a written thesis is approved. Only a total of 6 credits will count toward the degree.

PhEn 702 - Selected Topics in Pharmaceutical Engineering (3 credits )
Prerequisite: graduate standing and permission of the instructor. Topics of current interest in pharmaceutical engineering.

PhEn 725 - Independent Study (3 credits)
Prerequisites: permission from the graduate advisor (not the thesis advisor) in pharmaceutical engineering, as well as courses prescribed by a supervising faculty member (who is not the student's thesis advisor). This special course covers areas of study in which one or more students may be interested, but which is not of sufficiently broad interest to warrant a regular course offering. Students may not register for this course more than once with the same supervising faculty member.

PhEn 791 - Graduate Seminar (non-credit)
Required, when offered, of all pharmaceutical engineering graduate students receiving departmental or research-based awards. The student must register each semester until completion of the degree, if the Graduate Seminar is offered. Outside speakers and department members present their research for general discussion.