BINF 600/BINF 5100 - Introduction to Biomedical Informatics (3 credits)
Introduction to mainframe and microcomputer interactive computing environments: overview of computer applications for medical records; clinical, laboratory, pharmacy, education, and medical database management; patient care and hospital information systems using software for spreadsheets, database management, telecommunication, and literature retrieval. Also covers a decentralized hospital computer program, and computer-stored ambulatory record systems. Programming environment in relation to existing databases is discussed. Students complete small hands-on projects.

BINF 601/BINF 5005 - Health Care Information Systems (3 credits)
General systems theory applied to health care systems and information technology. Computer-based information system operation and management functions in the context of various professional settings, and the impact of information technology on health care management. Demonstrations of current health information systems emphasizing design, system components, data structures and database management. Costs and benefits of current applications, justification, specification and evaluation of computer systems, and the capacity for future modification and development of existing systems in various health care settings.

BINF 602/BINF 5020 - Biomedical Modeling and Decision-Making Systems (3 credits)
Introduction to use of differential equations and relevant mathematical concepts to describe health care and physiological systems. Methods and resources of computer simulation and modeling for analyzing and solving medical and health-care problems related to both organization and treatment, including decisions for effective information transfer, productivity and resource utilization, as well as physiological systems such as drug dosage, pulmonary transport, cardiac output, kidney function, and others.

BINF 603/BINF 5030 - Visualization in Biomedical Sciences (3 credits)
Fundamentals of biomedical signal and image processing including image digitization, display, and processing algorithms with emphasis on computer systems, processing methodologies, and display of images. Visualization procedures, tools and technologies for 3-D representation of images, animation and image manipulation are provided.

BINF 612/BINF 5125 - Clinical Problem Solving and Decision Making (3 credits)
An overview of computer methodology for clinical decision making. Application of decision trees for clinical and health care problems, estimation and revision of probabilities. Artificial intelligence, expert systems and decision-making techniques and their implementation as decision support systems in clinical and HIS settings. Examination of quantitative and symbolic approaches to medical decision making including application of statistical methods (discriminant and Bayesian statistics), decision analysis and utility theory.

BINF 613/BINF 5130 - Health Care Decision Support Systems (3 credits)
Overview of methods of decision support in health sciences, including artificial intelligence, Bayesian methods, classical multivariate analysis, dynamic screening (Markov) models, and theoretical and empirical limitations of these decision methods. Discussion of literature on human perception and judgment as well as practice on database management software and expert system tools to design decision support prototype systems for clinical, health care finance and patient management systems.

BINF 614/BINF 5135 - Clinical Systems Interface Design (3 credits)
Prerequisites: BINF 5100, BINF 5005 and BINF 4000 or equivalent. Practice of principles of interface design, data exchange, program-to-program communication, and knowledge-based systems using Windows-based GUI design packages. Exposure to application development tools with expert system shell capabilities and system integration tools with good communication interfacing between various hardware platforms from PCs to minicomputers and mainframes. Exploration of a wide array of user interface system design and development techniques. Term project using the GUI package required.

BINF 615/BINF 5150 - Seminar: Biomedical Teaching Systems Design (1 credits)
Based on knowledge gained from courses in biomedical informatics, students engage in serious discussion and analysis of the various aspects of computer-based instructional systems. Examples of technologies covered include: microcomputer courseware, CD/ROM, CD-I, DVI, instructional television, interactive microcomputer and videodisc systems, multimedia intelligent tutoring and expert systems, and instructional games and simulations.

BINF 621/BINF 5210 - Research Methods in Health Sciences (3 credits)
Use of computer as a tool for scientific inquiry including techniques for searching computer databases of research literature, and formulating problems and hypotheses for statistical analysis of educational, health services, laboratory and clinical data. Use of computers in management and analysis of health science data. Laboratory instruction in use and application of software packages for micro- and mainframe computers. Issues in the design, organization and operation of randomized controlled clinical trials and intervention studies, and analysis of qualitative and quantitative data.

BINF 622/BINF 5220 - Topics in Bioinformatics (3 credits)
Prerequisites: BINF 5005 or BINF 5010, and Chem 673 or equivalent. An extensive review of computational biology necessary to understand research and developments in bioinformatics. Topics include: covalent bonding, quantum mechanical basis of bond formation, 3-D structure of molecules, reaction mechanisms, catalysis, polymers, enzymes, thermodynamics and kinetics, metabolic pathways, and sequence and structure of macromolecules. Extensive use of computer approaches and computer graphical techniques to enhance interpretation of results.

BINF 623/BINF 5230 - Advances in Molecular and Cellular Genetics (3 credits)
Prerequisites: BINF 5005 or BINF 5010, and Chem 673 or equivalent. Extensive use of computer approaches to cover the following important areas: cell structure, intracellular sorting and signaling; structure and function of proteins; and nucleic acid; enzymology, membrane structure and function; DNA-replication, transcription and recombinant DNA molecules; genetic mutation, cell fusion, chromosomal mapping and gene transfer; and immunological principles applied to genetics.

BINF 631/BINF 5311 - Intelligent Instructional Systems (3 credits)
Current developments and trends in instructional technology applied to knowledge and learning in health science: processes of perception, learning, motivation, problem-solving and decision making in relation to the design of intelligent tutoring and educational expert systems. The students will work with knowledge engineering, expert system and authoring tools to develop intelligent tutorials and expert system models on selected/assigned topics.

BINF 632/BINF 5312 - Interactive Learning Systems for the Health Sciences (3 credits)
Introduction to use of interactive videodisc and CD-ROM technology for health sciences instructional software. Students try existing interactive software and videodiscs on biomedical subjects, and then design, edit and evaluate an interactive videodisc learning module of their own.

BINF 700/BINF 6000 - Directed Research/Project (6 credits)
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BINF 7910 - Research and Developments in Medical Informatics: Colloquium (1 credits)
This is a required course for all doctoral students. These seminar series prepare students for advanced research in biomedical informatics. Invited lecturers, experts in their various research domains, present major advances in biomedical informatics research. The lecturers are from within and outside the UMDNJ academic community as well as the health industry in general and affiliated industries.